Zeta Site was the location of a mysterious Engineer artifact capable of repelling the Xenomorphs, and which plays an integral role in the three campaigns of Primal Hunt.

This area later becomes known as Zeta Site, which was alluded to in AVP2 but never actually seen. The game establishes that that the Yautja discovered LV-1201 five-hundred years prior to the Weyland-Yutani Corporation, and reworked a portion of the Xenomorph Hive into a hunting ground for Young Bloods. The cause of its destruction, which was never fully explained in AVP2 is revealed in the expansion, as is the reasoning behind the Yautja's arrival on LV-1201 in the main game. Specifically, the player visits Pod 5, which was destroyed prior to the events in AVP2. The expansion revisits the Forward Observation Pods, a group of elevated habitation modules which comprise one of two main human facilities on the planet. In both time periods, the game takes place on the planet LV-1201, the site of AVP2.

The second time period is in 2230, about five weeks before the beginning of the Alien's campaign in Aliens versus Predator 2. The first is roughly five-hundred years before the events in Aliens versus Predator 2. The expansion takes place in two time periods.

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